Science cannot be only a remunerative recreation or adult lifelong medium-high income for turning up but must be purposed at the outset and reviewed all the way through to serve human and environmental health and wellbeing. As a neurolinguistics, communications, 2 – 5 Set Logic and philosophy of science student and ‘notable’ (let me put it this way: it would not reward any old-era authority in those fields or atmospheric science to ignore my work now) scholar I came across ‘Livescience’ in pursuit of the nano scale enhanced representation of neurons/ axons/ dendrites/ (telomeres, and yes?) article which appears in full below. – And terrific thanks to Sneha Khedkar for that and I’m sure retrospective permission to use your photograph.

So why run this obviously very large cash turnover organisation’s entire webpage including sketches of other articles?

..because we need a big picture to even begin to get to grips with the political culture of VAST global science funding the outsider might be completely forgiven (by me certainly) for thinking was only for counting and monitoring stuff then videoing it in optical terms no human naked eye may ever draw meaningful inferences or conclusions from but will be ‘fun’ or amusing to look at.

So here is a new beginning on the greatest and most important debate since the European nobleman and bloodthirsty racist young white-skinned warrior princeling out to prove himself Hernan Cortes stood (nobly of course) upon a peak in Darien and peered forth.

Of course it will be useful and contributory – i dont write chat or splatt

• Space
• Health
• Planet Earth
• Animals
• Archaeology
• Physics & Math
• Human Behavior
• More 

..as we address not only the multi-trillion dollar public relations and purportedly educational investment in fields of study found to be congenial to vast corporate financiers, supposedly charitable and religious NON TAX PAYING foundations and now, outrageously in my opinion, the governments of peak neoliberal free (but wildly oversubsidised) marketism managed for maximum, not optimal, corporate profit essentially by the frankly bastardised Keynesianism of manipulating inflation and interest rates for large investors and attendant suppression of real net wages with fewer & fewer hours of work over two or even three jobs exactly because those corporations – and criminal cartels, derivatives (futures) and cryptocurrency markets traders – hold, out of some now bizarre 1900s, 1920s or 1950s ideological slant that it is the right and duty of political parties of capital owners ever to combat and defeat the parties supported by people who earn their livings by the work of their hands & backs (labour) (not screens or playing markets white, grey or black) don’t want public controversy let alone public protest and disruption of their VAST carbon costly, emissions costly Alpha-profits infrastructure projects – including as ONLY ONE example in the array of fiscally profligate or largely non-productive costly, belated and lethally inefficient nuclear power as against the now unavoidable new era of micro- or community-scale electricity generation, STORAGE – production, distribution & exchange – how’s that you philosophical Marxists: nah, they go, we want great big centralised power stations hundreds of kilometres from the cities just like LB Johnson’s rural Alabama, Sir Thomas Playford’s South Australia and Iusuf Dzhugashvili’s Electrogorsk in the USSR – distribution and buyback within that vibrant and no doubt also economically reviving 100 square km geo-community. Nah, they go, we will milk all the fossil fuels markets onto 2060 now. – Oil, coal-seam gas AND coal. And the #Science backs us. Look what we can do when we got the most prestigious Australian science professor of the last 30 years to endorse our fraudulently managed AND technically nonsciencical carbon dioxide derivatives market credits scheme for us. You hippie clowns. We’ll lock you up..

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1. Health 
2. Mind 
3. Neuroscience

New 3D map charted with Google AI reveals ‘mysterious but beautiful’ slice of human brain

News

By Sneha Khedkar

published 10 hours ago

Harvard and Google researchers have collaborated to map a tiny fragment of an adult human brain in unprecedented detail.

Researchers built a 3D image of nearly every neuron and its connections within a small piece of human brain tissue. This version shows excitatory neurons colored by their depth from the surface of the brain. Blue neurons are those closest to the surface, and fuschia marks the innermost layer. The sample is approximately 3 millimeters wide. (Image credit: Google Research & Lichtman Lab (Harvard University). Renderings by D. Berger (Harvard University))

Researchers have mapped a tiny sliver of the human brain on an unprecedented scale, vividly detailing each brain cell, or neuron, and the intricate networks they form with other cells.

The groundbreaking brain map, which was constructed by Harvard and Google researchers, reveals roughly 57,000 neurons, 9 inches (230 millimeters) of blood vessels and 150 million synapses, or the connection points between neurons.

Dr. Jeff Lichtman, a professor of molecular and cellular biology at Harvard University who co-led the 10-year-long project, said he couldn’t believe the detailed map when he first saw it. “I had never seen anything like this before,” he told Live Science.  

READ MORE

Super-detailed map of brain cells that keep us awake could improve our understanding of consciousness‘Frankenstein’ mice with brain cells from rats raised in the lab

The human brain is a vastly complex organ with about 170 billion cells, including 86 billion neurons. Researchers have previously peeked into the brain at the scale of millimeters using magnetic resonance imaging (MRI). And more recently, advanced microscopy techniques have revealed details at a much smaller scale, improving our understanding of the brain’s inner workings. 

Related: Most detailed human brain map ever contains 3,300 cell types

Now, using these microscopy methods and an artificial intelligence (AI) system called machine learning, Lichtman and his colleagues have created a 3D map from a piece of brain at the scale of a nanometer, or 1-millionth of a millimeter. This presents a picture of the organ at the highest resolution scientists have ever achieved. 

The resulting cell atlas, described in the journal Science on May 9, is also available for scientists to peruse online.

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This map charts a tiny piece of brain with a volume of about 1 cubic millimeter — smaller than a grain of rice. A whole adult brain is a million times larger.

The brain fragment was sampled from a 45-year-old woman who had undergone brain surgery to treat epilepsy. Doctors removed the piece from the cerebral cortex, the outermost portion of her brain. After fixing the sample in preservatives, the researchers stained it with heavy metals to help them see the cells. They then embedded the tissue in resin and cut it into more than 5,000 slices, each measuring about 30 nanometers in thickness. 

Image 1 of 2

“That’s about a thousandth the thickness of a hair strand,” Lichtman said.The team scanned each of the slices with a high-speed electron microscope, which uses multiple beams of electrons to illuminate cells in the sample. They then sent the microscopy data to Google for further analysis using AI.

Google’s researchers used machine-learning models to identify the same object in different microscopic images and then create a 3D rendering of every object in all the images. They then electronically stitched the renderings together to reconstruct the whole sample in three dimensions. The final 3D map contains a mammoth 1.4 petabytes, or 1 million gigabytes, of data.

“The amount and complexity of the data generated in this project required Google’s ability to develop state of the art machine learning and AI algorithms to reconstruct the 3D connectome,” Viren Jain, a senior staff scientist at Google who co-led the project, told Live Science in an email.

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The scientists’ detailed map contains several surprises. For instance, they found that some of the neurons’ outgoing wires, or axons, wrapped themselves into knots, forming whorls that Jain described as “mysterious but beautiful.” The team also found rare connections between neurons, in which singular axons were linked to up to 50 synapses. 

“We’re still investigating the function of these connections, but they could explain how very fast responses, or very important memories are encoded,” Jain told Live Science. 

It remains to be seen whether the whorls and super-strong synapses have anything to do with the tissue donor’s epilepsy, or if they’d be seen in brains of people without the condition, Lichtman noted. He added that the team is now examining brain tissue from a person with Parkinson’s, so that may start to address the question.

He added it’s unlikely that brain tissue samples from any two people will look exactly the same, in part because the way the brain wires itself depends on an individual’s experiences.

The team next aims to map the entire brain of a mouse, which would be 500 times the size of this human brain sample. They’re starting with the hippocampus, a key region for learning and memory. 

“We have already begun the ambitious task,” Lichtman said.

Ever wonder why some people build muscle more easily than others or why freckles come out in the sun? Send us your questions about how the human body works to community@livescience.com with the subject line “Health Desk Q,” and you may see your question answered on the website! 

Sneha Khedkar

Live Science Contributor

Sneha Khedkar is a biologist-turned-freelance-science-journalist from India. She holds a master’s degree in biochemistry and a bachelor’s degree in microbiology and biochemistry. After her master’s, she worked as a research fellow for four years, studying stem cell biology. Her articles have been published in Scientific American, Knowable Magazine, and Undark, as well as several Indian platforms such as The Hindu and The Wire Science, among others. Besides writing, she enjoys a good cup of tea, reading novels and practicing yoga. 

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The above re-presented by

John Blundell

Australia

~ Must Become a Menace to My Enemies June Jordan (1936-2002)

^{Dedicated to the Poet Agostinho Neto, President of The People’s Republic of Angola: 1976}

1
I will no longer lightly walk behind
a one of you who fear me:
                                     Be afraid.
I plan to give you reasons for your jumpy fits
and facial tics
I will not walk politely on the pavements anymore
and this is dedicated in particular
to those who hear my footsteps
or the insubstantial rattling of my grocery
cart
then turn around
see me
and hurry on
away from this impressive terror I must be:
I plan to blossom bloody on an afternoon
surrounded by my comrades singing
terrible revenge in merciless
accelerating
rhythms
But
I have watched a blind man studying his face.
I have set the table in the evening and sat down
to eat the news.
Regularly
I have gone to sleep.
There is no one to forgive me.
The dead do not give a damn.
I live like a lover
who drops her dime into the phone
just as the subway shakes into the station
wasting her message
canceling the question of her call:
fulminating or forgetful but late
and always after the fact that could save or 
condemn me

I must become the action of my fate.

AT: ... there is far more to come here !

Qiu Xiaofei, Trotskyky Mountain, 2021, oil on linen, 150 × 90 cm.

If you have scrolled this far, I am just going to leave this here:

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~ You’re a political journalist and you’re not reading @Adam_Tooze daily?

You’re bullshit.

John Blundell

The post criminalisation, post medicalisation post normalisation of vile narcissistic behaviour, post faux feminisation human project..

Australia

Great Southern Lost Neoclassical Academic Triumphalist Brain-fart Land

Amiriyah Shelter Massacre 408 women children were killed

B’nai B’rith International is a 501 nonprofit Jewish service organization and was formerly a German Jewish cultural association. B’nai B’rith states that it is committed to the security and continuity of the Jewish people and the State of Israel and combating antisemitism and other forms of bigotry. Wikipedia

And from the The Tragedy of Julius Caesar (First Folio title: The Tragedie of Ivlivs Cæsar), often abbreviated as Julius Caesar, a history play and tragedy by William Shakespeare first performed in 1599, in which Brutus joins a conspiracy led by Cassius to assassinate Julius Caesar, to prevent him from becoming a tyrant, per courtesy of this X punter @abardseyeview4u..

“And drive away the vulgar from the streets.
So do you too, where you perceive them thick.
These growing feathers plucked from Caesar’s wing
Will make him fly an ordinary pitch,
Who else would soar above the view of men
And keep us all in servile fearfulness.”

We have indeed turned the tables – no New Testament Bible story this, it’s the Road to Serfdom NOT for Friedrich Hayek’s ‘Amtrak Joes,’ the pious polite parsimonious middle-income folk behind their desks and counters, but for every one of at least 7 billion so-called ‘semi-skilled’ human beings – the Gates Bannon Harvard University ascendancy.

May the fictive God of infinite androgynous internet wisdom stored in vast sheds draining rivers and fresh water aquifers help you all to corner it, pin it down and destroy it before it does you.

Trust me, I’m an economist whose brain does not whirr – or make tinkling cluncking noises.

JOHN BLUNDELL

Energy Health the Manmade Global Heating Apocalypse 2032 Quantum Relational Non-linear 2 to 5 set Logic the new Neurolinguistics the Mental Overhaul of Neo-classicism in 25 thousand Universities Philosophy of Science

PwC chief executive Kevin Burrowes says it is time to draw a line under the damaging tax leaks scandal that has plagued the big-four firm, while conceding the task of restoring its tattered reputation will take years.

After a horror period in which PwC was blackballed from lucrative federal government contracts, forced to hive off its 100-partner public sector consulting business for $1 and lost another 200-odd partners, Mr Burrowes said he was confident “enough progress” had been made to begin rebuilding.

“We feel we’re in a good position now to start to turn to a new chapter, look to the future and drive the firm with a new strategy,” he said.

“But for the 30-year veteran – parachuted in last year to lead the embattled partnership – risks abound in his aspiration to move on from revelations in The Australian Financial Review that PwC staff used confidential information to help clients sidestep tax laws the firm was helping to make.

“PwC still faces a hostile federal parliament – with all its powers to compel and hold witnesses in contempt, as well as a media megaphone in overdrive – that believes reform efforts to date amount to little more than “superficial commitments to change”.”

WHOOPSIE EVERYONE GEA has been busted not by @X really but by the number-crunching losers of #auspol Canberra Power – yes they call election strategising and criminal time-wasting that.

Mind the polycrisis.

John Blundell

Human & Ecological Health, Micro-Communal-Global Neurolinguistics, 2 to 5 Set Quantum Mathematics, Comprehensive Non-coercive Economic Reform, Philosophy of Science, #EducationForAll, FUTURES

Mount Barker, SA 🇦🇺🦘🌏, Fri 26 April 2024

With all thanks to Ketan Joshi

Anthony Albanese: the future fossil export king of Australia

Effortfully pouring fossil fuel subsidies into new coal and gas supply means worse emissions, because supply impacts demand.

Whatever Australia says about its climate plans – it is betting on catastrophic failure and planning to supply the fuel for that fire.

Science is in trouble on every continent affected by corporation-, investor-, financier-, grey-market (derivatives, cryptocurrency, neighborhood level ‘vice,’ drugs and crime)-, and black market (gangsters, drug importation, captive workers, trafficking, child exploitation, military/ regime death camps) -DRIVEN INFLATION with everyone who is angry about wasted public funds and lavishly publicly subsidised and Internal Revenue or national Taxation Office exempted, rebated and rewarded projects that do nothing for economies but nominally deploy tens of thousands of people on commonly tedious, repetitive, regimented if not INANE tasks (more suited to the fast and clever young) – in essentially counting living things, or in the case illustrated below, poisoned moribund things, and uploading terabytes of frankly junk data of no service to the human project but only to the billionaire cabal whereby it persists with an aspirationally ENDLESS FISCAL GROWTH AND ENRICHMENT TRIUMPHALIST IRRELEVANT SCIENCE¹ VENTURE FOR ITS ACOLYTES AND SUCK-HOLES in its nefarious business of erasing economy, languages, LIVING culture – or faith and society – for the fun and profit of itself while all around it millions are fraught, injured and killed by ‘want, squalor, disease,’ and my final two of William Beveridge’s 1942 socio-economic catastrophes, idleness and ignorance – these being the unmistakable PRIMARILY-INTENDED SOCIALLY ENGINEERED OUTCOMES of what we ALL glibly and erroneously call artificial intelligence – the genocidal assault by ideologically fascist, ‘totalist,’ ‘Aryan,’ unregulated and dysregulated neoliberal regimes against ALL non Anglo Celtic peoples, all non Christian and non Judaic religious practitioners or adherents – or just those like BILLIONS of us WHO ONCE TOOK SOLACE IN ANCIENT SCRIPTURE, OBSERVATION OR CEREMONY – ALL traditional and First Nations peoples, AND, as we come full circle back to the global economic crisis: SYSTEMATIC ATTACK ON THE INCOME, HOUSING and FOOD SECURITY of ALL MIDDLE-INCOME WORKING householders – manifestly and obviously to any skilled and capable economic planner INTENDED to reach right into the UPPER MIDDLE INCOME households and smash their savings each year ahead..

“Here, we present a AI-based model for predicting chemical toxicity. The model uses transformers to capture toxicity-specific features directly from the chemical structures and deep neural networks to predict effect concentrations. The model showed high predictive performance for all tested organism groups—algae, aquatic invertebrates and fish—and has, in comparison to commonly used QSAR methods, a larger applicability domain and a considerably lower error. When the model was trained on data with multiple effect concentrations (EC50/EC10), the performance was further improved. We conclude that deep learning and transformers have the potential to markedly advance computational prediction of chemical toxicity.”

https://www.biorxiv.org/content/10.1101/2023.04.17.537138v1

John

Energy Neurolinguistics Quantum Relations Health Philosophy of Science Australia🦘🇦🇺

¹ I do not include rockets and satellite telemetry in this discussion – by expenditure alone let alone pollution and the generation of millions more tonnes of carbon and other disastrous global heating gases, it steals from the wretched of the Earth (Frantz Fanon 1961 French Algeria specifically) AND EVERY YOUNG FAMILY OTHER THAN THE CHILDREN OF THE RICH – who will inevitably as the world stands this day pay a lethal personal price in any case.